Acetic Acid Irrigation
» Acetic Acid Irrigation is a sterile solution of Glacial Acetic Acid in Water for Injection. It contains, in each 100 mL, not less than 237.5 mg and not more than 262.5 mg of C2H4O2.
Packaging and storage Preserve in single-dose containers, preferably of Type I or Type II glass, and store at controlled room temperature. It may be packaged in suitable plastic containers.
Identification Evaporate 100 mL to about 10 mL: the resulting solution responds to the tests for Acetate 191.
Bacterial endotoxins 85 It contains not more than 0.5 Endotoxin Unit per mL.
pH 791: between 2.8 and 3.4.
Other requirements It meets the requirements under Injections 1, except that the container in which it is packaged may be designed to empty rapidly and may exceed 1000 mL in capacity.
Assay Pipet 50 mL of Irrigation into a 150-mL conical flask, add 2 drops of phenolphthalein TS, and titrate with 0.1 N sodium hydroxide VS. Each mL of 0.1 N sodium hydroxide is equivalent to 6.005 mg of C2H4O2.
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USP32NF27 Page 1420Pharmacopeial Forum: Volume No. 27(3) Page 2501