Isoniazid Oral Solution
» Isoniazid Oral Solution contains, in each 100 mL, not less than 0.93 g and not more than 1.10 g of isoniazid (C6H7N3O).
Packaging and storage— Preserve in tight, light-resistant containers.
Identification— A volume of Oral Solution equivalent to about 50 mg of isoniazid meets the requirements of Identification test B under Isoniazid.
Assay— Transfer an accurately measured volume of Oral Solution, equivalent to about 100 mg of isoniazid, to a 100-mL beaker. Add 50 mL of a mixture of 1 part of potassium bromide in 10 parts of dilute hydrochloric acid (1 in 6), and proceed as directed under Nitrite Titration 451, beginning with “cool to 15.” Each mL of 0.1 M sodium nitrite is equivalent to 13.71 mg of isoniazid (C6H7N3O).
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Behnam Davani, Ph.D., M.B.A.
Senior Scientist
(MDAA05) Monograph Development-Antivirals and Antimicrobials
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 2701
Pharmacopeial Forum: Volume No. 28(2) Page 311