Atenolol Oral Solution
» Atenolol Oral Solution contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of atenolol (C14H22N2O3). Prepare Atenolol Oral Solution at a 0.2% concentration, for example, as follows (see Pharmaceutical Compounding—Nonsterile Preparations 795).
Atenolol 200 mg
Glycerin 5 mL
Vehicle for Oral Suspension 45 mL
Vehicle for Oral Solution, Sugar
Free a sufficient quantity to make 100 mL
Calculate the quantity of each ingredient required for the total volume and atenolol strength to be prepared. Accurately weigh/measure each ingredient. Mix the Atenolol, previously pulverized, and Glycerin to form a smooth paste. Incorporate the Vehicle for Oral Suspension or an equal volume of Vehicle for Oral Solution, Sugar Free. [note—The Vehicle for Oral Suspension may be omitted.] Incorporate sufficient Vehicle for Oral Solution, Sugar Free in increments to bring to volume, and mix well. [note—Do not use a sucrose-containing vehicle for oral solution.] Package, and label.
Packaging and storage— Package in amber, tight containers, and store at controlled room temperature.
Labeling— Label it to state that it is to be shaken well before use, and discarded after 60 days. Label it to state that it is to be kept out of reach of children. Label it to indicate the nominal atenolol concentration.
Beyond-use date: not more than 60 days after preparation.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Rick G. Schnatz
Manager, Compounding Pharmacy Expert Committee
(CRX05) Compounding Pharmacy05
USP32–NF27 Page 1597
Pharmacopeial Forum: Volume No. 29(4) Page 1001