Atenolol Oral Solution
» Atenolol Oral Solution contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of atenolol (C14H22N2O3). Prepare Atenolol Oral Solution at a 0.2% concentration, for example, as follows (see Pharmaceutical CompoundingNonsterile Preparations 795).
Calculate the quantity of each ingredient required for the total volume and atenolol strength to be prepared. Accurately weigh/measure each ingredient. Mix the Atenolol, previously pulverized, and Glycerin to form a smooth paste. Incorporate the Vehicle for Oral Suspension or an equal volume of Vehicle for Oral Solution, Sugar Free. [noteThe Vehicle for Oral Suspension may be omitted.] Incorporate sufficient Vehicle for Oral Solution, Sugar Free in increments to bring to volume, and mix well. [noteDo not use a sucrose-containing vehicle for oral solution.] Package, and label.
Packaging and storage Package in amber, tight containers, and store at controlled room temperature.
Labeling Label it to state that it is to be shaken well before use, and discarded after 60 days. Label it to state that it is to be kept out of reach of children. Label it to indicate the nominal atenolol concentration.
Beyond-use date: not more than 60 days after preparation.
Auxiliary Information Please check for your question in the FAQs before contacting USP.
USP32NF27 Page 1597Pharmacopeial Forum: Volume No. 29(4) Page 1001