Allopurinol Oral Suspension
» Allopurinol Oral Suspension contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of allopurinol (C5H4N4O). Prepare Allopurinol Oral Suspension at a 2% concentration, for example, as follows (see Pharmaceutical Compounding—Nonsterile Preparations 795).
Allopurinol 2 g
Glycerin 5 mL
Vehicle for Oral Suspension 45 mL
Vehicle for Oral Solution, a sufficient
quantity to make
100 mL
Select the number of Tablets that contain the specified amount of Allopurinol and calculate the quantity of each ingredient required for the total amount to be prepared. Accurately count/weigh/measure each ingredient. Thoroughly pulverize the tablets. Mix the powdered Allopurinol Tablets and Glycerin to form a smooth paste, incorporate the Vehicle for Oral Suspension, add sufficient Vehicle for Oral Solution to volume, and mix well. Adjust the pH, if necessary. Package, and label.
Packaging and storage— Package in a tight container, and store at controlled room temperature.
Labeling— Label it to state that it is to be shaken well before use and that it is to be discarded after 60 days. Label it to state that it is to be kept out of the reach of children. Label it to indicate the nominal content of allopurinol in the Oral Suspension.
pH 791: an apparent pH between 6.5 and 7.5.
Beyond-use date: not more than 60 days after preparation.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Rick G. Schnatz
Manager, Compounding Pharmacy Expert Committee
(CRX05) Compounding Pharmacy05
USP32–NF27 Page 1452
Pharmacopeial Forum: Volume No. 29(4) Page 1000