Aminobenzoate Potassium Tablets
» Aminobenzoate Potassium Tablets contain not less than 90.0 percent and not more than 110.0 percent of the labeled amount of aminobenzoate potassium (C7H6 KNO2).
Packaging and storage— Preserve in well-closed containers.
Identification— Proceed as directed for Aminobenzoate Potassium Capsules, using 1 g of finely powdered Tablets.
Dissolution 711
Medium: water; 900 mL.
Apparatus 1: 100 rpm.
Time: 45 minutes.
Procedure— Determine the amount of C7H6KNO2 dissolved by employing UV absorption at the wavelength of maximum absorbance at about 270 nm on filtered portions of the solution under test, suitably diluted with Medium, in comparison with a Standard solution having a known concentration of USP Aminobenzoate Potassium RS in the same Medium.
Tolerances— Not less than 75% (Q) of the labeled amount of C7H6KNO2 is dissolved in 45 minutes.
Uniformity of dosage units 905: meet the requirements.
Standard preparation— Prepare a solution of USP Aminobenzoate Potassium RS having a known concentration of about 5 µg per mL.
Assay preparation and Procedure—Weigh and finely powder not fewer than 20 Tablets. Using a portion of the powdered Tablets, equivalent to about 100 mg of aminobenzoate potassium, proceed as directed in the Assay under Aminobenzoate Potassium Capsules.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Clydewyn M. Anthony, Ph.D.
(MDCCA05) Monograph Development-Cough Cold and Analgesics
Reference Standards Lili Wang, Technical Services Scientist
711 Margareth R.C. Marques, Ph.D.
Senior Scientist
(BPC05) Biopharmaceutics05
USP32–NF27 Page 1515