Creatinine
113.12» Creatinine contains not less than 98.5 percent and not more than 102.0 percent of C4H7N3O, as Creatinine, calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
Identification,
Infrared Absorption 
197K
.
197K.
Loss on drying 731—
Dry it at 105
for 3 hours: it loses not more than 3.0% of its weight.
731—
Dry it at 105 for 3 hours: it loses not more than 3.0% of its weight.
Residue on ignition 281:
not more than 0.2%.
281:
not more than 0.2%.
Heavy metals, Method I 231:
0.001%.
231:
0.001%.
Assay—
Dissolve about 40 mg of Creatinine, accurately weighed, in 10 mL of glacial acetic acid, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically, using a glass indicator electrode and a silver-silver chloride reference electrode containing a saturated solution of lithium perchlorate and silver chloride in glacial acetic acid (see Titrimetry 541). Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 11.312 mg of C4H7N3O.
541). Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 11.312 mg of C4H7N3O.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
| Monograph | Robert H. Lafaver, B.A.
Scientist 1-301-816-8335 |
(EM105) Excipient Monographs 1 |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1218