Carbinoxamine Maleate
406.86Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (Z)-2-butenedioate (1:1).
2-[p-Chloro-
-[2-(dimethylamino)ethoxy]benzyl]pyridine maleate (1:1)
[3505-38-2].» Carbinoxamine Maleate, dried at 105
for 2 hours, contains not less than 98.0 percent and not more than 102.0 percent of C16H19ClN2O·C4H4O4.
for 2 hours, contains not less than 98.0 percent and not more than 102.0 percent of C16H19ClN2O·C4H4O4.
Packaging and storage—
Preserve in tight, light-resistant containers.
Identification—
B:
Ultraviolet Absorption 
197U
—
197U—
Solution:
50 µg per mL.
Medium:
methanol.
Absorptivities at 260 nm, calculated on the dried basis, do not differ by more than 3.0%.
pH 791:
between 4.6 and 5.1, in a solution (1 in 100).
791:
between 4.6 and 5.1, in a solution (1 in 100).
Loss on drying 731—
Dry it at 105 for 2 hours: it loses not more than 0.5% of its weight.
731—
Dry it at 105 for 2 hours: it loses not more than 0.5% of its weight.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Ordinary impurities 466—
466—
Test solution:
chloroform.
Standard solution:
chloroform.
Eluant:
a mixture of cyclohexane, chloroform, and diethylamine (75:15:10).
Visualization:
1.
Assay—
Dissolve about 400 mg of Carbinoxamine Maleate, previously dried and accurately weighed, in 50 mL of glacial acetic acid, add 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue-green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 20.34 mg of C16H19ClN2O·C4H4O4.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
Chromatographic Column—
| Topic/Question | Contact | Expert Committee |
| Monograph | Daniel K. Bempong, Ph.D.
Senior Scientist 1-301-816-8143 |
(MDPS05) Monograph Development-Pulmonary and Steroids |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1791
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.