Carbinoxamine Maleate
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C16H19ClN2O·C4H4O4 406.86

Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (Z)-2-butenedioate (1:1).
2-[p-Chloro--[2-(dimethylamino)ethoxy]benzyl]pyridine maleate (1:1) [3505-38-2].
» Carbinoxamine Maleate, dried at 105 for 2 hours, contains not less than 98.0 percent and not more than 102.0 percent of C16H19ClN2O·C4H4O4.
Packaging and storage— Preserve in tight, light-resistant containers.
B: Ultraviolet Absorption 197U
Solution: 50 µg per mL.
Medium: methanol.
Absorptivities at 260 nm, calculated on the dried basis, do not differ by more than 3.0%.
Melting range 741: between 116 and 121, determined after drying.
pH 791: between 4.6 and 5.1, in a solution (1 in 100).
Loss on drying 731 Dry it at 105 for 2 hours: it loses not more than 0.5% of its weight.
Residue on ignition 281: not more than 0.1%.
Ordinary impurities 466
Test solution: chloroform.
Standard solution: chloroform.
Eluant: a mixture of cyclohexane, chloroform, and diethylamine (75:15:10).
Visualization: 1.
Assay— Dissolve about 400 mg of Carbinoxamine Maleate, previously dried and accurately weighed, in 50 mL of glacial acetic acid, add 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue-green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 20.34 mg of C16H19ClN2O·C4H4O4.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Daniel K. Bempong, Ph.D.
Senior Scientist
(MDPS05) Monograph Development-Pulmonary and Steroids
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 1791
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.