Carbachol Intraocular Solution
» Carbachol Intraocular Solution is a sterile solution of Carbachol in an aqueous medium. It contains not less than 90.0 percent and not more than 115.0 percent of the labeled amount of C6H15ClN2O2. It contains no preservatives or antimicrobial agents.
Packaging and storage— Preserve in tight containers, at controlled room temperature, and protect from freezing.
Labeling— Label it to indicate that it is for single-dose intraocular use only, and that the unused portion is to be discarded.
Identification— To 5 mL of Intraocular Solution, add 4 or 5 drops of saturated (filtered) ammonium reineckate solution: a pink precipitate is formed that is soluble in acetone; the acetone solution is red.
Sterility 71: meets the requirements.
pH 791: between 5.0 and 7.5.
Hypochlorite reagent and Standard preparation—Prepare as directed in the Assay under Carbachol Ophthalmic Solution.
Assay preparation— Dilute, if necessary, an accurately measured volume of Intraocular Solution quantitatively and stepwise with water to obtain a solution containing about 100 µg of carbachol per mL.
Procedure— Proceed as directed for Procedure in the Assay under Carbachol Ophthalmic Solution.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Ravi Ravichandran, Ph.D.
Senior Scientist
(MDPP05) Monograph Development-Psychiatrics and Psychoactives
Reference Standards Lili Wang, Technical Services Scientist
71 Radhakrishna S Tirumalai, Ph.D.
Senior Scientist
(MSA05) Microbiology and Sterility Assurance
USP32–NF27 Page 1783
Pharmacopeial Forum: Volume No. 33(2) Page 213