Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride.
Choline chloride, carbamate [51-83-2].
» Carbachol contains not less than 99.0 percent and not more than 101.0 percent of C6H15ClN2O2, calculated on the dried basis.
Packaging and storage Preserve in tight containers.
B: A solution (1 in 20) meets the requirements for the silver nitrate precipitate test for Chloride 191.
Melting range 741: between 200 and 204, with some decomposition.
Loss on drying 731 Dry about 1 g, accurately weighed, at 105 for 2 hours: it loses not more than 2.0% of its weight.
Residue on ignition 281: not more than 0.1%.
Ordinary impurities 466
Test solution: a mixture of methanol and water (4:1).
Standard solution: a mixture of methanol and water (4:1).
Assay Dissolve about 400 mg of Carbachol, accurately weighed, in a mixture of 10 mL of glacial acetic acid and 10 mL of mercuric acetate TS. Add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 18.27 mg of C6H15ClN2O2.
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USP32NF27 Page 1783Pharmacopeial Forum: Volume No. 33(2) Page 213