Carbachol
182.65Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride.
Choline chloride, carbamate
[51-83-2].» Carbachol contains not less than 99.0 percent and not more than 101.0 percent of C6H15ClN2O2, calculated on the dried basis.
Packaging and storage—
Preserve in tight containers.
Identification—
B:
A solution (1 in 20) meets the requirements for the silver nitrate precipitate test for Chloride 
191
.
191.
Loss on drying 731—
Dry about 1 g, accurately weighed, at 105
for 2 hours: it loses not more than 2.0% of its weight.
731—
Dry about 1 g, accurately weighed, at 105 for 2 hours: it loses not more than 2.0% of its weight.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Ordinary impurities 466—
466—
Test solution:
a mixture of methanol and water (4:1).
Standard solution:
a mixture of methanol and water (4:1).
Eluant:
alcohol.
Visualization:
16.
Assay—
Dissolve about 400 mg of Carbachol, accurately weighed, in a mixture of 10 mL of glacial acetic acid and 10 mL of mercuric acetate TS. Add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 18.27 mg of C6H15ClN2O2.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
| Monograph | Ravi Ravichandran, Ph.D.
Senior Scientist 1-301-816-8330 |
(MDPP05) Monograph Development-Psychiatrics and Psychoactives |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1783
Pharmacopeial Forum: Volume No. 33(2) Page 213