Calcium Pantothenate
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C18H32CaN2O10 476.53

-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), (R)-.
Calcium d-pantothenate (1:2) [137-08-6].
» Calcium Pantothenate is the calcium salt of the dextrorotatory isomer of pantothenic acid. It contains not less than 5.7 percent and not more than 6.0 percent of nitrogen (N), and not less than 8.2 percent and not more than 8.6 percent of calcium (Ca), both calculated on the dried basis.
Packaging and storage— Preserve in tight containers.
USP Reference standards 11
USP Beta Alanine RS Click to View Structure .

USP Calcium Pantothenate RS.
B: A solution (1 in 20) responds to the tests for Calcium 191.
Specific rotation 781S: between +25.0 and +27.5.
Test solution: 50 mg per mL, in water.
Alkalinity— Dissolve 1.0 g in 15 mL of carbon dioxide-free water in a small flask. As soon as solution is complete, add 1.0 mL of 0.10 N hydrochloric acid, then add 0.05 mL of phenolphthalein TS, and mix: no pink color is produced within 5 seconds.
Loss on drying 731 Dry it at 105 for 3 hours: it loses not more than 5.0% of its weight.
Heavy metals 231 Dissolve 1.0 g in 25 mL of water: the limit is 0.002%.
Ordinary impurities 466
Test solution: water.
Standard solution: water. Use USP Beta Alanine RS, in place of USP Calcium Pantothenate RS, as the Standard.
Eluant: a mixture of alcohol and water (65:35).
Visualization: 4.
Limit: 1.0%.
Nitrogen content, Method I 461 Proceed as directed except to weigh accurately about 500 mg.
Content of calcium —Dissolve about 800 mg of Calcium Pantothenate, accurately weighed, in 150 mL of water containing 2 mL of 3 N hydrochloric acid. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue, and titrate with 0.05 M edetate disodium VS until the solution is a distinct blue in color. Each mL of 0.05 M edetate disodium is equivalent to 2.004 mg of Ca.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Curtis Phinney

(DSN05) Dietary Supplements - Non-Botanicals
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 1768
Pharmacopeial Forum: Volume No. 32(1) Page 62
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.