Bromodiphenhydramine Hydrochloride
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C17H20BrNO·HCl 370.71

Ethanamine, 2-(4-bromophenyl)phenylmethoxy-N,N-dimethyl-, emsp;hydrochloride.
2-(p-Bromo--phenylbenzyl)oxy-N,N-dimethylethylamine hydrochloride [1808-12-4].
» Bromodiphenhydramine Hydrochloride contains not less than 98.0 percent and not more than 101.0 percent of C17H20BrNO·HCl, calculated on the dried basis.
Packaging and storage— Preserve in tight containers.
B: Ultraviolet Absorption 197U
Solution: 15 µg per mL.
Medium: 0.1 N sulfuric acid.
Absorptivities at 228 nm, calculated on the dried basis, do not differ by more than 3.0%.
Melting range 741: between 148 and 152.
Loss on drying 731 Dry it at 105 for 3 hours: it loses not more than 0.5% of its weight.
Assay— Dissolve about 700 mg of Bromodiphenhydramine Hydrochloride, accurately weighed, in 50 mL of glacial acetic acid, and add 10 mL of benzene and 15 mL of mercuric acetate TS. Add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 37.07 mg of C17H20BrNO·HCl.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Daniel K. Bempong, Ph.D.
Senior Scientist
(MDPS05) Monograph Development-Pulmonary and Steroids
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 1710
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.