Aqueous Calamine Cream

Aqueous Calamine Cream contains 4% w/w of Calamine and 3% w/w of Zinc Oxide in a suitable oil-in-water emulsified basis.

The following formula and directions apply.

Calamine	40 g
Zinc Oxide	30 g
Liquid Paraffin	200 g
Self-emulsifying Glyceryl Monostearate	50 g
Cetomacrogol Emulsifying Wax	50 g
Phenoxyethanol	5 g
Purified Water, freshly boiled and cooled	Sufficient to produce 1000 g

Melt the Cetomacrogol Emulsifying Wax with the Self-emulsifying Glyceryl Monostearate, add the Liquid Paraffin and heat to about 60°. Dissolve the Phenoxyethanol in about 620 g of Purified Water at about 60°, add the oily phase to the phenoxyethanol solution and mix. Stir until cool, add sufficient Purified Water to produce 930 g and mix. Triturate the Calamine and the Zinc Oxide and incorporate in the cream.

The cream complies with the requirements stated under Topical Semi-solid Preparations and with the following requirements.

4.3 to 5.2% w/w.

The residue obtained in the Assay is yellow when hot and white when cool.

Gently heat 4 g, taking precautions to avoid loss caused by spitting, until the basis is completely volatilised or charred, increase the temperature until the carbon is removed and ignite the residue to constant weight. Each g of residue is equivalent to 0.8034 g of Zn.