Sodium Thiosulfate Injection

Sodium Thiosulphate Injection

Sodium Thiosulfate Injection is a sterile solution of Sodium Thiosulfate in Water for Injections.

The injection complies with the requirements stated under Parenteral Preparations and with the following requirements.

95.0 to 105.0% of the stated amount.

A clear, colourless solution.

A. Yields the reactions characteristic of sodium salts, Appendix VI.

B. To 1 mL add iodinated potassium iodide solution, the reagent is initially decolourised, until a very faint persistent yellow colour appears. The mixture does not yield reaction A characteristic of sulfates, Appendix VI.

C. To 5 mL add 1 mL of hydrochloric acid. A white precipitate which quickly changes to yellow is formed, and a gas is evolved which turns starch iodate paper blue.

pH, 7.0 to 9.0, Appendix V L.

Dilute a volume containing 0.5 g of Sodium Thiosulfate to about 20 mL with water and titrate with 0.05m iodine VS using 1 mL of starch solution, added towards the end of the titration, as indicator. Each mL of 0.05m iodine VS is equivalent to 24.82 mg of Na₂S₂O₃,5H₂O.