• British Pharmacopoeia Volume V
  • Appendices
  • Appendix I D. Buffer Solutions

Total Ionic Strength Adjustment Buffer
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Total Ionic Strength Adjustment Buffer Dissolve 58.5 g of sodium chloride R, 57.0 mL of glacial acetic acid R, 61.5 g of sodium acetate R and 5.0 g of cyclohexylene-dinitrilotetra-acetic acid R in water R and dilute to 500.0 mL with the same solvent. Adjust to pH 5.0 to 5.5 with a 335 g/l solution of sodium hydroxide R and dilute to 1000.0 mL with distilled water R.