• British Pharmacopoeia Volume III
  • Formulated Preparations: Specific Monographs

Sodium Bicarbonate Ear Drops

General Notices
Definition

Sodium Bicarbonate

5 g

Glycerol

30 mL

Purified Water, freshly boiled and cooled

Sufficient to produce 100 mL

Extemporaneous preparation

The following directions apply.

Dissolve the Sodium Bicarbonate in about 60 mL of Purified Water, add the Glycerol and sufficient Purified Water to produce 100 mL and mix.

Sodium Bicarbonate Ear Drops should be recently prepared.

The ear drops comply with the requirements stated under Ear Preparations and with the following requirements.

Content of sodium bicarbonate, NaHCO3

4.75 to 5.25% w/v.

Weight per mL

1.10 to 1.12 g, Appendix V G.

Assay

To 5 mL add 20 mL of water and titrate with 0.1m hydrochloric acid VS using methyl orange-xylene cyanol FF solution as indicator. Each mL of 0.1m hydrochloric acid VS is equivalent to 8.401 mg of NaHCO3.