Fischer Oxazole Synthesis

E. Fischer, Ber. 29, 205 (1896).

Condensation of equimolar amounts of aldehyde cyanohydrins and aromatic aldehydes in dry ether in the presence of dry hydrochloric acid:

R. H. Wiley, Chem. Rev. 37, 410 (1945); J. W. Cornforth, R. H. Cornforth, J. Chem. Soc. 1949, 1028; J. W. Cornforth, Heterocycl. Compd. 5, 309 (1957); T. Onaka, Tetrahedron Lett. 1971, 4391.