Delépine Reaction (Delépine Amine Synthesis)

M. Delépine, Compt. Rend. 120, 501 (1895); 124, 292 (1897).

Preparation of primary amines by reaction of alkyl halides with hexamethylenetetramine followed by acid hydrolysis of the formed quaternary salts:

S. J. Angyal, Org. React. 8, 197 (1954); Y. Basace et al., Bull. Soc. Chim. France 1971, 1468. Synthetic applications: S. N. Quessy et al., J. Chem. Soc. Perkin Trans. I 1979, 512; S. Brandänge, B. Rodriguez, Synth. Commun. 1988, 347; R. A. Henry et al., J. Org. Chem. 55, 1796 (1990).