Tamibarotene
Structural Formula Vector Image
Title: Tamibarotene
CAS Registry Number: 94497-51-5
CAS Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
Additional Names: p-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylcarbamoyl)benzoic acid
Manufacturers' Codes: AM-80
Trademarks: Tamibaro (Toko)
Molecular Formula: C22H25NO3
Molecular Weight: 351.44
Percent Composition: C 75.19%, H 7.17%, N 3.99%, O 13.66%
Literature References: Synthetic retinoic acid receptor-a/b-selective retinoid. Prepn: K. Shudo, EP 170105 (1986 to Sumitomo; Yoshitomi); idem, US 4703110 (1987); H. Kagechika et al., J. Med. Chem. 31, 2182 (1988). HPLC determn in plasma: M. Itoh, G. Kominami, J. Immunoassay Immunochem. 22, 213 (2001). Receptor binding studies in human leukemia cells: Y. Hashimoto et al., Jpn. J. Cancer Res. 79, 473 (1988). Series of articles on pharmacokinetics and reproductive and developmental toxicity: K. Mizojiri et al., Arzneim.-Forsch. 47, 59, 195, 201, 259, 270 (1997). Inhibition of myeloma cell-induced angiogeneis: T. Sanda et al., Leukemia 19, 901 (2005). Clinical evaluation in acute promyelocytic leukemia: K. Shinjo et al., Int. J. Hematol. 72, 470 (2000).
Properties: Colorless prisms from ethyl acetate-n-hexane, mp 231-232°.
Melting point: mp 231-232°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Retinoids and Analogs.

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