Ridogrel
Structural Formula Vector Image
Title: Ridogrel
CAS Registry Number: 110140-89-1
CAS Name: 5-[[(E)-[3-Pyridinyl[3-(trifluoromethyl)phenyl]methylene]amino]oxy]pentanoic acid
Manufacturers' Codes: R-68070
Molecular Formula: C18H17F3N2O3
Molecular Weight: 366.33
Percent Composition: C 59.02%, H 4.68%, F 15.56%, N 7.65%, O 13.10%
Literature References: Combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist. Prepn: E. J. E. Freyne et al., EP 221601; eidem, US 4963573 (1987, 1990 both to Janssen). Clinical pharmacology: B. Hoet et al., Thromb. Haemostasis 64, 87 (1990); C. Weber et al., ibid. 68, 214 (1992). Clinical study in peripheral arterial obstructive disease: J. De Cree et al., Int. Angiol. 12, 59 (1993); as adjunct to thrombolysis in acute myocardial infarction: RAPT Investigators, Circulation 89, 588 (1994).
Properties: Crystals from diisopropyl ether/hexane (2:1), mp 70.3°.
Melting point: mp 70.3°
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic; Thromboxane A2-Receptor Antagonist; Thromboxane A2-Sythetase Inhibitor.

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