LBF

Literature References: Growth factor occurring in products derived from both animal and plant sources and in culture filtrate of certain microorganisms: Williams et al., J. Biol. Chem. 177, 933 (1949); Vitucci et al., Arch. Biochem. Biophys. 34, 409 (1951); Peters et al., J. Am. Chem. Soc. 75, 1688 (1953). Contains pantetheine, q.v. which is oxidized during purification to the disulfide, pantethine, q.v. Natural occurrence of several different forms of LBF each being a mixed disulfide of pantetheine: Rasmussen et al., Proc. Soc. Exp. Biol. Med. 73, 658 (1950); Brown, Snell, J. Biol. Chem. 198, 375 (1952). Coenzyme A digested with intestinal phosphatase shows 2-4 LBF-active components: Long, Williams, J. Bacteriol. 61, 195 (1951). Review: Snell, Brown, "Pantethine and Related Forms of the Lactobacillus Bulgaricus Factor (LBF)" in Adv. Enzymol. 14, 49-71 (1953).