IACFT
Structural Formula Vector Image
Title: IACFT
CAS Registry Number: 180468-34-2
CAS Name: (1R,2S,3S,5S)-3-(4-Fluorophenyl)-8-[(2E)-3-(iodo-2-propenyl)]-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
Additional Names: 2b-carboxymethoxy-3b-(4-fluorophenyl)-N-(1-iodoprop-1-en-3-yl)nortropane
Trademarks: Altropane (Organix)
Molecular Formula: C18H21FINO2
Molecular Weight: 429.27
Percent Composition: C 50.36%, H 4.93%, F 4.43%, I 29.56%, N 3.26%, O 7.45%
Literature References: Cocaine analog with dopamine transport inhibitor activity. Radiolabeled form designed for SPECT brain imaging. Prepn: D. R. Elmaleh et al.,WO 9511901; eidem, US 5493026 (1995, 1996 both to Gen. Hosp. Corp., Harvard College, Organix and Northeastern Univ.); and receptor binding studies: eidem, J. Nucl. Med. 37, 1197 (1996). Series of articles on pharmacology and binding studies: B. K. Madras et al., Synapse 29, 93-127 (1998). Clinical evaluation in Parkinson's disease: A. J. Fischman et al., ibid. 128. CE determn in plasma: K. Hettiarachchi et al., J. Chromatogr. A 895, 87 (2000).
Properties: White solid, mp 115-116°,
Melting point: mp 115-116°,
 
Derivative Type: 123I-Labeled form
CAS Registry Number: 208517-65-1
 
Derivative Type: 125I-Labeled form
CAS Registry Number: 180268-78-4
 
Therap-Cat: 123I-labeled form as diagnostic aid (radioactive imaging agent).

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