Hellebrin
Structural Formula Vector Image
Title: Hellebrin
CAS Registry Number: 13289-18-4
CAS Name: 3-[(6-Deoxy-4-O-b-D-glucopyranosyl-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxobufa-20,22-dienolide
Additional Names: hellebrigenin glucorhamnoside
Molecular Formula: C36H52O15
Molecular Weight: 724.79
Percent Composition: C 59.66%, H 7.23%, O 33.11%
Literature References: Cardiac glycoside isolated from rhizome of Helleborus niger L., Ranunculaceae: Karrer, Festschr. Emil Barell 1936, 238, C.A. 31, 23488 (1937). Structure: Karrer, Helv. Chim. Acta 26, 1353 (1943); Wissner, Kating, Planta Med. 20, 344 (1971).
Properties: Crystals from hot methanol, mp 283-284°. [a]D20 -23.4° (50% methanol). Sol in dil alcohol; less sol in methanol, ethanol; slightly sol in water. Practically insol in ether. MLD in guinea pigs: 0.85 mMole/kg, Klup, Arch. Exp. Pathol. Pharmakol. 252, 314 (1966).
Melting point: mp 283-284°
Optical Rotation: [a]D20 -23.4° (50% methanol)
Toxicity data: MLD in guinea pigs: 0.85 mMole/kg, Klup, Arch. Exp. Pathol. Pharmakol. 252, 314 (1966)
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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