Halothane
Structural Formula Vector Image
Title: Halothane
CAS Registry Number: 151-67-7
CAS Name: 2-Bromo-2-chloro-1,1,1-trifluoroethane
Additional Names: bromochlorotrifluoroethane; 1,1,1-trifluoro-2,2-chlorobromoethane
Trademarks: Fluothane (Ayerst); Rhodialothan (Nattermann)
Molecular Formula: C2HBrClF3
Molecular Weight: 197.38
Percent Composition: C 12.17%, H 0.51%, Br 40.48%, Cl 17.96%, F 28.88%
Line Formula: CF3CHClBr
Literature References: Prepn from a mixt of F3CCH2Cl and F3CCBr2Cl: Suckling, Raventos, US 2921098 (1960 to I.C.I.); by rearrangement of F2BrCCHFCl: Scherer, Kühn, US 2959624 (1960 to Hoechst); from BrClCHCBrCl2: Chapman, McGinty, GB 805764 (1958 to I.C.I.); from Br2ClCCF3: McGinty, US 3082263 (1963 to I.C.I.); Madai, Muller, J. Prakt. Chem. 19, 83 (1963). Enantiomeric resolution: J. Meinwald et al., Science 251, 560 (1991). Comprehensive description: R. D. Daley, Anal. Profiles Drug Subs. 1, 119-147 (1972).
Properties: Non-flammable, highly volatile liquid. Characteristic, sweetish, not unpleasant odor. d420 1.871. bp 50.2°; bp243 20°. nD0 1.3697. Sensitive to light, may be stabilized with 0.01% thymol. Soly in water 0.345%. Miscible with petr ether, other fat solvents.
Boiling point: bp 50.2°; bp243 20°
Index of refraction: nD0 1.3697
Density: d420 1.871
CAUTION: Potential symptoms of overexposure are irritation of eyes, skin, respiratory system; confusion, drowsiness, dizziness, nausea, analgesia, anesthesia; cardiac arrhythmia; liver and kidney damage; decreased audio visual performance. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 156.
Therap-Cat: Anesthetic (inhalation).
Therap-Cat-Vet: Anesthetic (inhalation).
Keywords: Anesthetic (Inhalation).

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