Halobetasol Propionate
Structural Formula Vector Image
Title: Halobetasol Propionate
CAS Registry Number: 66852-54-8
CAS Name: (6a,11b,16b)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
Additional Names: 21-chloro-6a,9-difluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate; ulobetasol propionate
Manufacturers' Codes: BMY-30056; CGP-14458
Trademarks: Ultravate (BMS)
Molecular Formula: C25H31ClF2O5
Molecular Weight: 484.96
Percent Composition: C 61.92%, H 6.44%, Cl 7.31%, F 7.84%, O 16.50%
Literature References: Trihalogenated corticosteroid structurally related to clobetasol, q.v. Prepn: J. Kalvoda, G. Anner, DE 2743069; eidem, US 4619921 (1978, 1986 both to Ciba-Geigy). Clinical pharmacology in psoriatic patients: W. A. Watson et al., Pharmacotherapy 10, 107 (1990). Clinical trial in localized vitiligo: L. Xunquan et al., Int. J. Dermatol. 29, 295 (1990).
Properties: Crystals from methylene chloride/ether, mp 220-221°.
Melting point: mp 220-221°
Therap-Cat: Anti-inflammatory.
Keywords: Glucocorticoid.

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