Cuproxoline
Structural Formula Vector Image
Title: Cuproxoline
CAS Registry Number: 13007-93-7
CAS Name: Tetrahydrogen bis[8-hydroxy-5,7-quinolinedisulfonato(3-)-N1,O8]cuprate(4-) compd with N-ethylethanamine (1:4)
Additional Names: 8-hydroxy-5,7-quinolinedisulfonic acid copper derivative compound with diethylamine; cupric bis[8-hydroxyquinoline di(diethylammonium sulfonate)]; copper DOS
Trademarks: Dicuprene (UCB); Cujec (Mallinckrodt); Cuprimyl (M & B)
Molecular Formula: C34H56CuN6O14S4
Molecular Weight: 964.65
Percent Composition: C 42.33%, H 5.85%, Cu 6.59%, N 8.71%, O 23.22%, S 13.30%
Literature References: Clinical efficacy in treatment of arthritis: W. C. Kuzell et al., Ann. Rheum. Dis. 10, 328 (1951). Veterinary use as parenteral copper supplement: I. J. Cunningham, N. Z. Vet. J. 7, 15 (1959); N. F. Suttle, Vet. Rec. 109, 304 (1981); G. J. Judson et al., Aust. Vet. J. 61, 40 (1984). Review of use of organic copper complexes in treatment of rheumatoid and degenerative diseases: J. R. J. Sorenson, W. Hangarter, Inflammation 2, 217-238 (1977). Review of veterinary use: W. M. Allen, C. B. Mallinson, Vet. Rec. 114, 451-454 (1984).
Properties: Green platelets. Sol in water, giving a dark-green soln. A 10% aq soln is almost neutral and can be sterilized by autoclaving. LD50 i.m. in rats: 126 mg/kg (Kuzell).
Toxicity data: LD50 i.m. in rats: 126 mg/kg (Kuzell)
Therap-Cat: Antirheumatic.
Therap-Cat-Vet: Copper supplement.
Keywords: Antiarthritic/Antirheumatic.

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