Clocapramine
Structural Formula Vector Image
Title: Clocapramine
CAS Registry Number: 47739-98-0
CAS Name: 1¢-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4¢-bipiperidine]-4¢-carboxamide
Additional Names: 3-chloro-5-[3-(4-piperidino-4-carbamoylpiperidino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 3-chlorocarpipramine; clocarpramine; CCP
Molecular Formula: C28H37ClN4O
Molecular Weight: 481.07
Percent Composition: C 69.91%, H 7.75%, Cl 7.37%, N 11.65%, O 3.33%
Literature References: Prepn: M. Nakanishi, C. Tashiro, DE 1905765; eidem, US 3668210 (1969, 1972, both to Yoshitomi); M. Nakanishi et al., J. Med. Chem. 13, 644 (1970). Pharmacology and toxicity: M. Nakanishi et al., Arzneim.-Forsch. 21, 391 (1971). Effect on metabolism of serotonin and catecholamines: M. Nakanishi, M. Setoguchi, ibid. 23, 806 (1973). Metabolism: M. Nakanishi et al., J. Pharm. Soc. Jpn. 91, 1042 (1971). HPLC determn in plasma: K. Hikida et al., Anal. Sci. 6, 367 (1990). Review: Jpn. Med. Gaz. 10(7), 5 (1973).
 
Derivative Type: Dihydrochloride monohydrate
CAS Registry Number: 60789-62-0
Manufacturers' Codes: Y-4153
Trademarks: Clofekton (Yoshitomi)
Molecular Formula: C28H37ClN4O.2HCl.H2O
Molecular Weight: 572.01
Percent Composition: C 58.79%, H 7.22%, Cl 18.59%, N 9.79%, O 5.59%
Properties: White, bitter tasting, crystalline powder, mp 267°. Soly in water: <3.5 g/100 ml. Freely sol in glacial acetic acid. Practically insol in ether, acetone. LD50 in mice, rats (mg/kg): 160, 125 i.p.; 2550, 6800 orally (Nakanishi).
Melting point: mp 267°
Toxicity data: LD50 in mice, rats (mg/kg): 160, 125 i.p.; 2550, 6800 orally (Nakanishi)
 
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Other Tricyclics.

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