Thiphenamil
Structural Formula Vector Image
Title: Thiphenamil
CAS Registry Number: 82-99-5
CAS Name: a-Phenylbenzeneethanethioic acid S-[2-(diethylamino)ethyl]ester
Additional Names: diphenylthioacetic acid S-(2-diethylaminoethyl) ester; diphenylthiolacetic acid 2-diethylaminoethyl ester; S-[2-(diethylamino)ethyl]diphenylthioacetate; b-diethylaminoethyl diphenylthioacetate
Molecular Formula: C20H25NOS
Molecular Weight: 327.48
Percent Composition: C 73.35%, H 7.69%, N 4.28%, O 4.89%, S 9.79%
Literature References: Smooth muscle relaxant. Prepn: Richardson, US 2390555 (1945 to Wm. P. Poythress); Clinton, US 2510773 (1950 to Sterling Drug); Richardson, J. Pharm. Sci. 55, 1316 (1966). Mechanism of action study: Y. Kimoto et al., J. Urol. 144, 1497 (1990). Clinical evaluation in detrusor incontinence: C. E. Constantinou, Urol. Int. 48, 42 (1992).
 
Derivative Type: Hydrochloride
CAS Registry Number: 548-68-5
Trademarks: Trocinate (Poythress)
Molecular Formula: C20H25NOS.HCl
Molecular Weight: 363.94
Percent Composition: C 66.00%, H 7.20%, N 3.85%, O 4.40%, S 8.81%, Cl 9.74%
Properties: Rosettes of tiny needles from benzene + petr ether, large prisms from abs ethanol + ethyl acetate, mp 129-130°. Sol in water. Aq solns are about neutral to litmus.
Melting point: mp 129-130°
 
Therap-Cat: Antispasmodic.

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