Olsalazine
Structural Formula Vector Image
Title: Olsalazine
CAS Registry Number: 15722-48-2
CAS Name: 3,3¢-Azobis(6-hydroxybenzoic acid)
Additional Names: C.I. Mordant Yellow 5; 3,3¢-dicarboxy-4,4¢-dihydroxyazobenzene; 5,5¢-azobis(salicylic acid); azodisal
Molecular Formula: C14H10N2O6
Molecular Weight: 302.24
Percent Composition: C 55.63%, H 3.33%, N 9.27%, O 31.76%
Literature References: Dimer of mesalamine, q.v., originally used as a mordant dye. Prepn: DE 278613; C. Mettler, US 1157169 (1914, 1915 both to J. R. Geigy). Improved prepn: K. H. Agback, A. S. Nygren, EP 36636; eidem, US 4528367 (1981, 1985 both to Pharmacia AB). HPLC determn in biological samples: R. A. van Hogezand et al., J. Chromatogr. 305, 470 (1984). In vitro effect on fecal bacteria: H. Sandberg-Gertzen et al., Scand. J. Gastroenterol. 20, 607 (1985). Clinical pharmacokinetics and metabolism: C. P. Willoughby et al., Gut 23, 1081 (1982). Clinical trial in ulcerative colitis: H. Sandberg-Gertzen et al., Gastroenterology 90, 1024 (1986). Review of clinical experience in inflammatory bowel disease: A. N. Wadworth, A. Fitton, Drugs 41, 647-664 (1991).
 
Derivative Type: Disodium salt
CAS Registry Number: 6054-98-4
Additional Names: Azodisal sodium; disodium azodisalicylate; C.I. 14130
Manufacturers' Codes: CJ-91B
Trademarks: Dipentum (Pfizer)
Molecular Formula: C14H8N2Na2O6
Molecular Weight: 346.20
Percent Composition: C 48.57%, H 2.33%, N 8.09%, Na 13.28%, O 27.73%
Properties: Yellow crystalline powder, mp 240° (dec). Sol in water, DMSO. Practically insol in ethanol, chloroform, ether.
Melting point: mp 240° (dec)
 
Use: Mordant dye for wool.
Therap-Cat: Anti-inflammatory (gastrointestinal).
Keywords: Anti-inflammatory (Gastrointestinal); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives.

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