Mitoguazone
Structural Formula Vector Image
Title: Mitoguazone
CAS Registry Number: 459-86-9
CAS Name: 2,2¢-(1-Methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide]
Additional Names: 1,1¢-[(methylethanediylidene)dinitrilo]diguanidine; methylglyoxal bis(guanylhydrazone); pyruvaldehyde bis(amidinohydrazone)
Molecular Formula: C5H12N8
Molecular Weight: 184.20
Percent Composition: C 32.60%, H 6.57%, N 60.83%
Literature References: Polyamine biosynthesis inhibitor. Prepn: F. Baiocchi et al., J. Med. Chem. 6, 431 (1963); V. T. Oliverio, C. Denham, J. Pharm. Sci. 52, 202 (1963). Experimentally effective against myelogenous leukemia: Freireich et al., Cancer Chemother. Rep. 16, 183 (1962). HPLC determn in plasma: C.-L. Cheng et al., J. Chromatogr. B 793, 281 (2003). Review of clinical experience: D. D. Von Hoff, Ann. Oncol. 5, 487-493 (1994).
Properties: Prepd as the hemihydrate; off-white crystals from isopropyl alcohol, dec 225°. uv max at pH 1: 283 nm (e 38400); at pH 11: 325 nm (e 33500). pKa: 7.63, 9.05.
pKa: pKa: 7.63, 9.05
Absorption maximum: uv max at pH 1: 283 nm (e 38400); at pH 11: 325 nm (e 33500)
 
Derivative Type: Dihydrochloride
CAS Registry Number: 7059-23-6
Manufacturers' Codes: NSC-32946
Trademarks: Methyl-GAG (Dakota Pharm)
Molecular Formula: C5H12N8.2HCl
Molecular Weight: 257.12
Percent Composition: C 23.36%, H 5.49%, N 43.58%, Cl 27.58%
Properties: Crystals from acetone, dec 256-257°.
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.

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