Metofoline
Structural Formula Vector Image
Title: Metofoline
CAS Registry Number: 2154-02-1
CAS Name: 1-(p-Chlorophenethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline
Additional Names: 1-(p-chlorophenethyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; methopholine
Manufacturers' Codes: Ro-4-1778/1
Molecular Formula: C20H24ClNO2
Molecular Weight: 345.86
Percent Composition: C 69.45%, H 6.99%, Cl 10.25%, N 4.05%, O 9.25%
Literature References: Prepn: A. Brossi et al., Helv. Chim. Acta 43, 1459 (1960); H. Besendorf et al., US 3067203 (1962 to Hoffmann-La Roche). Metabolism: G. Sciorelli, Experientia 23, 934 (1967). Review of pharmacology, toxicity and clinical experience: A. Brossi et al., in Analgetics: Medicinal Chemistry Series of Monographs vol. 5, G. deStevens, Ed. (Academic Press, New York, 1965) p 281-330.
Properties: Colorless leaflets from aqueous methanol, mp 110-111°. LD50 in mice, rats (mg/kg): 180, 400 s.c.; 180, 400 orally; 70, 100 i.p.; in mice, rabbits (mg/kg): 70, 30 i.v. (Brossi, 1965).
Melting point: mp 110-111°
Toxicity data: LD50 in mice, rats (mg/kg): 180, 400 s.c.; 180, 400 orally; 70, 100 i.p.; in mice, rabbits (mg/kg): 70, 30 i.v. (Brossi, 1965)
 
Derivative Type: Hydrochloride
Properties: Crystals, mp 105-106°. uv max (ethanol): 283, 287 nm.
Melting point: mp 105-106°
Absorption maximum: uv max (ethanol): 283, 287 nm
 
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic).
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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