Mesoridazine
Structural Formula Vector Image
Title: Mesoridazine
CAS Registry Number: 5588-33-0
CAS Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine
Additional Names: thioridazine-2-sulfoxide
Manufacturers' Codes: TPS-23
Molecular Formula: C21H26N2OS2
Molecular Weight: 386.57
Percent Composition: C 65.25%, H 6.78%, N 7.25%, O 4.14%, S 16.59%
Literature References: Dopamine receptor blocking agent; analog of thioridazine. Prepn: Renz et al., US 3084161 (1963 to Sandoz). Pharmacology and toxicology: Loew et al., Boll. Chim. Farm. 106, 332-371 (1967). Effects on dopaminergic function in comparison with sulforidazine and thioridazine, q.q.v.: D. M. Niedzwiecki et al., J. Pharmacol. Exp. Ther. 228, 636 (1984); C. D. Kilts et al., ibid. 231, 334 (1984). GLC determn in plasma: E. C. Dinovo et al., J. Pharm. Sci. 65, 667 (1976). Clinical evaluation in sleep disorders: K. Adam et al., Br. J. Clin. Pharmacol. 3, 157 (1976); as antipsychotic: R. Axelsson, Curr. Ther. Res. 21, 587 (1977). Toxicity studies: S. Maruyama et al., Niigata Igakkai Zasshi 81, 611 (1967), C.A. 68, 76856h (1968). Brief description: J. Am. Med. Assoc. 216, 313 (1971).
Properties: Oily product.
 
Derivative Type: Benzenesulfonate
CAS Registry Number: 32672-69-8
Additional Names: Mesoridazine besylate
Manufacturers' Codes: NC-123
Trademarks: Lidanar (Sandoz); Lidanil (Sandoz); Serentil (Boehringer, Ing.)
Molecular Formula: C27H32N2O4S3
Molecular Weight: 544.75
Percent Composition: C 59.53%, H 5.92%, N 5.14%, O 11.75%, S 17.66%
Properties: LD50 in mice (mg/kg): 33 i.v.; 611 s.c.; 346 orally (Maruyama).
Toxicity data: LD50 in mice (mg/kg): 33 i.v.; 611 s.c.; 346 orally (Maruyama)
 
Derivative Type: Tartrate
Molecular Formula: C25H32N2O7S2
Molecular Weight: 536.66
Percent Composition: C 55.95%, H 6.01%, N 5.22%, O 20.87%, S 11.95%
Properties: Crystals from ethyl acetate, mp 115-120°.
Melting point: mp 115-120°
 
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.

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