Mepixanox
Structural Formula Vector Image
Title: Mepixanox
CAS Registry Number: 17854-59-0
CAS Name: 3-Methoxy-4-(1-piperidinylmethyl)-9H-xanthen-9-one
Additional Names: 3-methoxy-4-piperidinylmethyl-9-oxo-10-oxa-9,10-dihydroanthracene; mepixanthone
Trademarks: Pimexone (Formenti)
Molecular Formula: C20H21NO3
Molecular Weight: 323.39
Percent Composition: C 74.28%, H 6.55%, N 4.33%, O 14.84%
Literature References: Prepn: M. Sparaci, ZA 6902150 (1969 to Mondi), C.A. 72, 111,300d (1970). Alternate process: D. Milani, US 3646030 (1972 to Mondi). CNS activity: P. Da Re et al., J. Med. Chem. 13, 527 (1970). Pharmacology: R. Guira et al., Minerva Pneumolog. 21, 317 (1982). Pharmacokinetics in man: G. Grossi et al., Curr. Ther. Res. 38, 141 (1985). HPLC determn in serum: G. Grossi et al., J. Chromatogr. 309, 214 (1984). Clinical comparison with doxapram, q.v., in chronic bronchopulmonary disease: M. Parziale et al., G. Ital. Mal. Torace 38, 323 (1984). Clinical evaluations in chronic obstructive lung disease: D. Olivieri et al., Arch. Monaldi Tisiol. Mal. Appar. Respir. 35, 117 (1980); L. Bertoli et al., Minerva Pneumolog. 23, 323 (1984).
Properties: White crystalline powder from ethyl acetate, mp 159-160°. LD50 i.p. in mice: 70.73 mg/kg (Sparaci).
Melting point: mp 159-160°
Toxicity data: LD50 i.p. in mice: 70.73 mg/kg (Sparaci)
 
Derivative Type: Hydrochloride
Molecular Formula: C20H22ClNO3
Molecular Weight: 359.85
Percent Composition: C 66.75%, H 6.16%, Cl 9.85%, N 3.89%, O 13.34%
Properties: White crystalline solid from ethanol, mp >200° (dec).
Melting point: mp >200° (dec)
 
Therap-Cat: Respiratory stimulant.
Keywords: Respiratory Stimulant.

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