Doxofylline
Structural Formula Vector Image
Title: Doxofylline
CAS Registry Number: 69975-86-6
CAS Name: 7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(1,3-dioxolan-2-ylmethyl)theophylline; 2-(7¢-theophyllinemethyl)-1,3-dioxolane; doxophylline; dioxyfilline
Manufacturers' Codes: ABC-12/3
Trademarks: Ansimar (ABC); Maxivent; Ventax (Robert)
Molecular Formula: C11H14N4O4
Molecular Weight: 266.25
Percent Composition: C 49.62%, H 5.30%, N 21.04%, O 24.04%
Literature References: Prepn: U. Avico et al., Farmaco Ed. Sci. 17, 73 (1962). Use as bronchodilator: BE 868556; J. S. Franzone, T. Tamietto, US 4187308 (1978, 1980 to Istituto Biologico Chemioterapico ABC). Pharmacology: J. S. Franzone et al., Farmaco Ed. Sci. 36, 201 (1981). Pharmacodynamics and toxicity in rats: J. S. Franzone et al., ibid. 220. HPLC determn in pharmaceutical compositions: C. Badini et al., Farmaco Ed. Prat. 37, 320 (1982). Clinical trial in obstructive pneumopathy: C. Bucca et al., Int. J. Clin. Pharmacol. Res. 11, Suppl 1, 101 (1982).
Properties: Crystals, mp 144-145.5°. Sol in water, acetone, ethyl acetate, benzene, chloroform, dioxane, hot methanol or hot ethanol. Practically insol in ethyl ether or petr ether. LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone).
Melting point: mp 144-145.5°
Toxicity data: LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone)
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Xanthine Derivatives.

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