Benztropine Mesylate
403.548-Azabicyclo[3.2].1octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate.
3
-(Diphenylmethoxy)-1h,5h-tropane methanesulfonate
[132-17-2].» Benztropine Mesylate contains not less than 98.0 percent and not more than 100.5 percent of C21H25NO·CH4O3S, calculated on the dried basis.
Packaging and storage—
Preserve in tight containers.
Loss on drying 
731
—
Dry it at 105
for 2 hours: it loses not more than 5.0% of its weight.
731—
Dry it at 105 for 2 hours: it loses not more than 5.0% of its weight.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Assay—
Transfer about 60 mg of Benztropine Mesylate, accurately weighed, to a 125-mL separator. Dissolve in 25 mL of water, add 5 mL of sodium carbonate TS, and extract with four 10-mL portions of chloroform. Wash the combined chloroform extracts with about 10 mL of water, and extract the wash solution with 5 mL of chloroform. Filter the combined chloroform extracts through a tightly packed pledget of cotton, and wash the cotton with about 5 mL of chloroform. Add methyl red TS, and titrate the chloroform solution with 0.01 N perchloric acid in dioxane VS. Perform a blank determination, and make any necessary correction. Each mL of 0.01 N perchloric acid is equivalent to 4.035 mg of C21H25NO·CH4O3S.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
Chromatographic Column—
| Topic/Question | Contact | Expert Committee |
| Monograph | Ravi Ravichandran, Ph.D.
Senior Scientist 1-301-816-8330 |
(MDPP05) Monograph Development-Psychiatrics and Psychoactives |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1650
Pharmacopeial Forum: Volume No. 29(6) Page 1848
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.