Silver Nitrate Ophthalmic Solution
» Silver Nitrate Ophthalmic Solution is a solution of Silver Nitrate in a water medium. It contains not less than 0.95 percent and not more than 1.05 percent of AgNO3. The solution may be buffered by the addition of Sodium Acetate.
Packaging and storage—
Preserve it protected from light, in inert, collapsible capsules or in other suitable single-dose containers.
Clarity and color of solution—
It is clear and colorless.
Sterility 
71
:
meets the requirements.
71:
meets the requirements.
pH 791:
between 4.5 and 6.0.
791:
between 4.5 and 6.0.
Assay—
Place 5 mL of Ophthalmic Solution, accurately measured, in a conical flask, dilute with 20 mL of water, add 1 mL of nitric acid and 1 mL of ferric ammonium sulfate TS, and titrate with 0.02 N ammonium thiocyanate VS. Each mL of 0.02 N ammonium thiocyanate is equivalent to 3.397 mg of AgNO3.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
| Monograph | Behnam Davani, Ph.D., M.B.A.
Senior Scientist 1-301-816-8394 |
(MDAA05) Monograph Development-Antivirals and Antimicrobials |
| 71 |
Radhakrishna S Tirumalai, Ph.D.
Senior Scientist 1-301-816-8339 |
(MSA05) Microbiology and Sterility Assurance |
USP32–NF27 Page 3554