Oxazepam
286.712H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (±)-.
(±)-7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
[604-75-1].» Oxazepam contains not less than 98.0 percent and not more than 102.0 percent of C15H11ClN2O2, calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
Identification—
B:
Ultraviolet Absorption 
197U
—
197U—
Solution:
4 µg per mL.
Medium:
alcohol.
Absorptivities at 229 nm, calculated on the dried basis, do not differ by more than 3.0%.
pH 791:
between 4.8 and 7.0, in an aqueous suspension (1 in 50).
791:
between 4.8 and 7.0, in an aqueous suspension (1 in 50).
Loss on drying 731—
Dry it at a pressure below 5 mm of mercury at 105
for 3 hours: it loses not more than 2.0% of its weight.
731—
Dry it at a pressure below 5 mm of mercury at 105 for 3 hours: it loses not more than 2.0% of its weight.
Residue on ignition 281:
not more than 0.3%.
281:
not more than 0.3%.
Assay—
Transfer about 400 mg of Oxazepam, accurately weighed, to a beaker, dissolve in 100 mL of dimethylformamide, and titrate with 0.1 N tetrabutylammonium hydroxide VS, determining the endpoint potentiometrically using a calomel-glass electrode system and taking precautions against absorption of atmospheric carbon dioxide. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N tetrabutylammonium hydroxide is equivalent to 28.67 mg of C15H11ClN2O2.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
Chromatographic Column—
| Topic/Question | Contact | Expert Committee |
| Monograph | Ravi Ravichandran, Ph.D.
Senior Scientist 1-301-816-8330 |
(MDPP05) Monograph Development-Psychiatrics and Psychoactives |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 3154
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.