Isoniazid Oral Solution
» Isoniazid Oral Solution contains, in each 100 mL, not less than 0.93 g and not more than 1.10 g of isoniazid (C6H7N3O).
Packaging and storage—
Preserve in tight, light-resistant containers.
Identification—
A volume of Oral Solution equivalent to about 50 mg of isoniazid meets the requirements of Identification test B under Isoniazid.
Assay—
Transfer an accurately measured volume of Oral Solution, equivalent to about 100 mg of isoniazid, to a 100-mL beaker. Add 50 mL of a mixture of 1 part of potassium bromide in 10 parts of dilute hydrochloric acid (1 in 6), and proceed as directed under Nitrite Titration 
451
, beginning with “cool to 15
.” Each mL of 0.1 M sodium nitrite is equivalent to 13.71 mg of isoniazid (C6H7N3O).
451, beginning with “cool to 15.” Each mL of 0.1 M sodium nitrite is equivalent to 13.71 mg of isoniazid (C6H7N3O).
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
| Monograph | Behnam Davani, Ph.D., M.B.A.
Senior Scientist 1-301-816-8394 |
(MDAA05) Monograph Development-Antivirals and Antimicrobials |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 2701
Pharmacopeial Forum: Volume No. 28(2) Page 311