Gramicidin
Gramicidin. Gramicidin [1405-97-6]. » Gramicidin is an antibacterial substance produced by the growth of Bacillus brevis Dubos (Fam. Bacillaceae). It may be obtained from tyrothricin. It has a potency of not less than 900 µg of gramicidin per mg, calculated on the dried basis.
Packaging and storage
Preserve in tight containers.
Melting temperature, Class Ia 741:
not lower than 229, determined after drying.
Crystallinity 695:
meets the requirements.
Loss on drying 731
Dry about 100 mg in a capillary-stoppered bottle in vacuum at 60 for 3 hours: it loses not more than 3.0% of its weight.
Residue on ignition 281:
not more than 1.0%, the charred residue being moistened with 2 mL of nitric acid and 5 drops of sulfuric acid.
Assay
Proceed with Gramicidin as directed under AntibioticsMicrobial Assays 81.
Auxiliary Information
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USP32NF27 Page 2528
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