433.

Williamson Synthesis

A. W. Williamson, J. Chem. Soc. 4, 229 (1852).

Synthesis of symmetrical or unsymmetrical ethers by alkylation of alkoxides with primary alkyl halides, sulfates or tosylates; usually by an SN2 mechanism:

Reviews: H. Feuer, J. Hooz in The Chemistry of the Ether Linkage, S. Patai, Ed. (Wiley, New York, 1967) pp 446-460; H. O. Kalinowski et al., Ber. 114, 477 (1981). Applications on solid support: A. Weissberg et al., J. Comb. Chem. 3, 154 (2001). Catalytic synthesis of alkyl aryl ethers: E. Fuhrmann, J. Talbiersky, Org. Process Res. Dev. 9, 206 (2005).